Molecular Biology of GIST

I. ICC & KIT Become the Focus

KIT (CD117)

Interstitial Cells of Cajal

Slide 5

Slide 6

Slide 7

Slide 8

GIST
Spindle cell                        Epithelioid

II. Evidence for KIT Activation as a Crucial Oncogenic Mechanism in Most GISTs

Slide 11

GIST Cytogenetics - Mechanisms of Neoplastic Progression

GIST:  Clonal Evolution of Cytogenetic Abnormalities

Summary

Molecular Targets in GIST cells