April 2012
- LRG mourns the loss of a great friend, Jeroen Pit
- GDOL Update: Speakers announced
- LRG Research Team meets in Leuven, Belgium: leaves with renewed energy & commitment to finding the cure for GIST
- Meet our new Montana local rep: Dirk Niebaum
- Cellular origin of GIST from the “good” cells’ perspective
- Alianza GIST meets in Miami
- And they’re off! 1st ‘Harness a Cure’ is a success
- NJ GIST gathering serves up support & smoothies
- NoCal GISTers meet!
- New report finds most hospital errors go unreported
- Happy Cancerversary to Brenda Bannon!
- Thomas G. Overley, 1952-2012: Toledo lawyer played guitar, sang in group
- Durham lived life with passion and pride
- Did You Hear? Did You Know?
- Arizona GISTers meet!
- Spunky Texan fought GIST bravely
- Calendar
Archive
July 2009
Phase I evaluation of SF1126, a vascular targeted PI3K inhibitor, administered twice weekly IV
Abstract 2558, E. Gabriela Chiorean, MD, Indiana University Simon Cancer Center, Indianapolis, IN
Written by
Jim Hughes
Four GIST patients have entered this Phase 1 trial of PI3K inhibitor SF1126. Preliminary results presented show that three had stable disease lasting from eight to 20 weeks. Additionally, it was reported that so far SF1126 has been well-tolerated and that there have been no clinically significant changes reported in glucose or insulin levels.This is important since PI3K inhibitors can have off-target effects on glucose metabolism.
This data is preliminary since the study is ongoing and still accepting patients. This trial would be a good choice for patients failing imatinib and sunitinib and in need of alternatives to off-label options. Chiorean also expressed interest in a Phase 2 study of this drug in GIST.
Abstract #: 2558
0 Comments