October 2007
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Building blocks of tumor progression
by Brian Rubin, M.D.
There are many lines of evidence that have shown that an activating mutation in KIT or PDGFRA within ICC or a related pre-ICCtype cell, causes the cell to proliferate in an uncontrolled fashion, resulting in a GIST.
- Reports of good Nexavar response The Life Raft Group has received two recent reports of patients that had failed multiple therapies and then apparently responded to Nexavar (also known as sorafenib or BAY 43-9006). In both cases, the patients had failed Gleevec, Sutent and AMN107.
- August blessings for April: a baby born in the LRG! by Erin Kristoff On August 19 at 6:52 AM, LRG member and pediatric GIST patient, April Calloway Stephens gave birth to a healthy baby girl named Mary Catherine Stephens (nine pounds, one ounce, 21 inches in case anyone is wondering). This is the first time a pediatric member of the LRG has had a child.
- October 2007 internationalclinical trial update

