October 2009
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Defining molecular mechanisms of imatinib treatment in GIST
by Anette Duensing, M.D.
Gastrointestinal stromal tumors (GISTs) are caused by mutations in the KIT or PDGFRA (platelet-derive growth factor receptor alpha) receptor tyrosine kinase genes and can successfully be treated with imatinib mesylate (Gleevec®). However, despite dramatic response rates and more than 85 percent of the patients initially benefitting from therapy, imatinib treatment is not a cure.
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Jerry Call: the man behind the scene
by Erin Kristoff
You sit alone in a dreary doctor’s office; evidence of his medical expertise and importance adorn the walls. Maybe you sit there with a loved one, equally as scared and unprepared as you...
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LifeFest 2010: Celebrating a decade of life
by Marisa Bolognese
It has been a remarkable decade for the GIST community as scientific discovery, medical treatment and drug development have put GIST at the cutting edge of cancer treatment and care.
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It’s time to consider mutational status for resistant GIST patients: PDGFRA Mutations
by Jerry Call
This is the second article in a series discussing mutational status and resistant GIST. In the last article we began with a brief overview and wild-type GIST. In this article we focus on PDGFRA mutations with an emphasis on the imatinibresistant D842V mutation.
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REGISTER Study Open in Australia, New Zealand and South Korea
by Jim Hughes
An interesting Phase 2 REGISTER study is ongoing and actively recruiting at 15 sites in Australia. Two sites in New Zealand and two sites in South Korea are also planned.
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October 2009 clinical trials update
by Jim Hughes
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Donor appreciation never gets old
When compiling the list of donors for the year 2008, the LRG inadvertently left out a number of donors who should have been included. At the LRG, we are grateful for each and every donation and are sincerely moved by the continued generosity of our supporters...
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Chicago-area GISTers meet!
Last month’s Chicago-area meeting, was a reunion of sorts for many attendees...
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Rowan passes with family by his side
Mr. Kenneth Ray Rowan, of Muse, Oklahoma passed away peacefully at his residence September 30, 2009 while in the presence of family and close friends. He is now in his new home, serving the Lord as he did here on earth, with love and joy.
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Nurit Mantz, wonderful wife and mother, passes away at 46
...She was dedicated to her family, especially to her two sons and their basketball and baseball interests. She attended all their games and kept large scrapbooks of their achievements...
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