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The Life Raft Group - Ensuring that no one has to face GIST alone

The Life Raft Group - Ensuring that no one has to face GIST alone

Hi, my name is Rachel. I'm 20 years old and from the U.K.

Hi, my name is Rachel. I'm 20 years old and from the U.K.

The Life Raft Group - Ensuring that no one has to face GIST alone

About GIST

Understanding GIST
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All About Gleevec (Glivec)

General Information | Response Rate & Related Exon Mutations
Dosage | Side Effects | Drug Interactions

Drug Interactions

Other drugs affect Gleevec | Gleevec affects other drugs
Long list of inhibitors and inducers | Drug interaction glossary | Article about Gleevec Drug Interactions

Long list of Inhibitors and Inducers of CYP3A4 and CYP2D6

Drugs that may alter Gleevec plasma concentrations (Long List) also see: www.drug-interactions.com NOTE: CYP3A4 is the main enzyme that metabolizes Gleevec and therefore effects may be more pronounced that those related to CYP2D6
Drugs that Induce CYP3A4¹	Drugs that Inhibit CYP3A4¹
Reduce Gleevec levels	Increase Gleevec levels
May result in sub-therapeutic levels of Gleevec	May result in above normal levels of Gleevec
May be more of a concern for lower doses of Gleevec	May be more of a concern for higher doses of Gleevec
CYP3A4 inducers	CYP3A4 inhibitors
Carbamezepine Dexamethasone Ethosuximide Glucocorticoids Griseofulvin Phenytoin Primidone Progesterone Rifabutin Rifampin Nafcillin Nelfinavir Nevirapine Oxcarbazepine Phenobarbital Phenylbutazone Rofecoxib (mild) St John's wort Sulfadimidine Sulfinpyrazone Troglitazone	Aminodarone Anastrozole Azithromzcin Cannabinoids Cimetidine Clarithromycin Clotrimazole Cyclosporine Danazol Delavirdine Dexamethasone Diethyldithiocarbamate Diltiazem Dirithyromycin Disulfiram Entacapone (high dose) Erythromycin Ethinyl estradiol Fluconazole Fluoxetine Fluvoaxamine Gestodene Grapefruit juice Indinavir Isoniazid Ketoconazole Metronidazole Mibefradil Miconazole Nefazodone Nelfinavir Nevirapine Norfloxacin Norfluoxetine Omeprazole Oxiconazole Paroxetine (weak) Propoxyphene Quinidine Quinine Quinupristine and dalfopristin Ranitidine Ritonavir Saquinavir Sertindole Sertraline Troglitazone Troleandomycin Valproic acid
Drugs that Induce CYP2D6²	Drugs that Inhibit CYP3A4¹
May Reduce Gleevec levels	May Increase Gleevec levels
May result in sub-therapeutic levels of Gleevec	May result in above normal levels of Gleevec
May be more of a concern for lower doses of Gleevec	May be more of a concern for higher doses of Gleevec
CYP2D6 inducers	CYP2D6 inhibitors
Dexamethasone Rifampin	Amiodarone Celecoxib Chloroquine Chlorpromazine Cimetidine Citalopram Clomipramine Codeine Deiavirdine Desipramine Dextroprpoxyphene Diltiazem Doxorubicin Entacapone (high dose) Fluoxetine Fluphenazine Fluvaxamine Haloperidol Labetalol Lobeline Lomustine Methadone Mibefradil Moclobemide Nortuloxeline Paroxetine Perphenazine Propafenone Quinacrine Quinidine Ranitadine (ranitidine, Zantac) Risperidone (weak) Ritonavir Serindole Sertraline (weak) Thioridazine Valproic acid Venlafaxine (weak) Vinblastine Vincristine Vinorelbine Yohimbine

1. List of "medications to avoid (if possible)" given to phase II Gleevec/GIST patients.
2. www.drug-interactions.com