All About Gleevec (Glivec)

Drug Interactions

Other drugs affect Gleevec | Gleevec affects other drugs
Long list of inhibitors and inducers | Drug interaction glossary | Article about Gleevec Drug Interactions

Particular caution is recommended when administering Gleevec with CYP3A4 substrates that have a narrow therapeutic window (e.g. cyclolsporine and pimozide).

Major drugs that may have their plasma concentration altered by Gleevec

also see: www.drug-interactions.com
Drugs listed as substrates of CYP3A4/5, CYP2D6 and CYP2C9
may have their plasma concentrations raised by Gleevec

Gleevec Inhibits CYP3A4¹	Gleevec Inhibits CYP2D6¹	Gleevec Inhibits CYP2C9¹
Increases drug levels	Increases drug levels	Increases drug levels
May result in higher levels of drugs	May result in higher levels of drugs	May result in higher levels of drugs
CYP3A4 substrates (drugs that use CYP3A4)	CYP2D6 substrates (drugs that use CYP2D6)	CYP2C9 substrates (drugs that use CYP2C9)
Many drugs are metabolized by this pathway. Simvastatin interactions have been reported. For a larger list, see www.drug-interactions.com	Warfarin	Warfarin

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1. Gleevec prescribing information, USA, T2005-18
2. www.drug-interactions.com